Matt Breida Quarterback Nick Mullens Jersey ,Chargers The San Francisco 49ers listed running backs Matt Breida and Alfred Morris as questionable for Week 4, but both appear set to play. The team will release their inactives at 11:55 a.m. PT, but Adam Schefter and Ian Rapoport are both reporting the two backs are expected to play.Both reported Breida was ahead of Morris late in the week. Morris was not listed on Wednesday, but then showed up on Thursday and Friday as limited with a knee injury. Breida injured his knee in Week 3 but finished out the game. He was limited on Wednesday, then bumped up to full on Thursday, then down to limited on Friday. Shanahan said Breida had been up and down this week, and they cut him back on Friday, “just trying to manage the wear and tear.”Having both backs will be critical in C.J. Beathard’s first start of the season. Breida leads the NFL in yards per carry at 8.6. He was tied with Ezekiel Elliott for the league leading in rushing yards (274), but Todd Gurley passed them on Thursday. Gurley has 338 yards after his performance on TNF.Breida has been a home-run hitter for the 49ers, while Morris has handled more of the dirty work. The veteran has 153 yards this season, and is averaging 3.8 yards per carry. Morris had been out-snapping Breida the first two weeks Rookie Nick Mullens Jersey , but we saw Breida get more snaps (29 to 23) even with the scary second quarter knee injury. That will be something to track in Week 4 given how well Breida has performed through three weeks.49ers fantasy football pick-ups, drops for Week 5 There isn’t much to note as far as fantasy pick-ups for Week 5. With us figuring out who C.J. Beathard’s favorite target outside of George Kittle is, there’s no sure things on the San Francisco 49ers. We’ll jump into some pickups in the NFL at large, but not this week. There are still some considerations and starts to make in anticipation of the matchup against a bad Arizona Cardinals squad. Let’s take a look. As always, percentage owned numbers are based on Yahoo! leagues.Pick-ups49ers D/STWeek 4 stats: 29 PA, one interception, one touchdownMany of you have asked if we would even consider starting the 49ers D/ST against a bad, BAD Arizona Cardinals team. Our answer is: It depends. Now, before we go further, that’s not a good answer for a fantasy pick-up. If your league is scored using only points allowed by the D/ST, and you are hurting for a streaming defense Nick Mullens Jersey , be it waiver positioning, a drought of teams, or a deep league, then maybe--and we say this with little confidence--maybe the 49er D/ST is an option this week. If your league awards points for sacks and interceptions (or in mine where you get a lot of points for a defense performing well), then stay far, far away from this. The 49ers will not generate enough of anything to be a game-changer. There are much worse defenses to pick up this week, and if you are desperate, the 49ers can be plugged in to hold down the fort in a crucial bye. But a lot of things need to be going against you to even consider this (like every team having two D/ST’s on their roster which is questionable to say the least). Pick up or don’t pick up: Don’t pick them up. Must-Start Status AlertGeorge Kittle% Owned: 88Week 4 stats: 6 receptions, 125 yards, one touchdownMr. Kittle’s and bits has gone from a sleeper draft choice, to a big pickup Nick Mullens 49ers Jersey , to a must-start now that C.J. Beathard is chucking the ball to him. None of Beathard’s pass-catchers are standing out and we all know Garrett Celek isn’t going to do anything with his opportunities besides bat away potential touchdown passes. The 49ers get the Arizona Cardinals this week. As I’ve said, a bad Cardinals team. Slot Kittle in as your tight end this week if you haven’t already. And if you’re one of those lucky ones who have both Kittle and say Travis Kelce/Rob Gronkowski/Zach Ertz, put Kittle in as your flex (if allowed). Yes, he’s going to go off that much. We said last week Kittle was in must-start status and he didn’t disappoint. The Cardinals are much, much worse than the Chargers. Start with confidence. The only time Kittle should be benched is if your league rules do not allow you to flex him when having one of the above three tight ends.Pick up or don’t pick up: 88 percent? Some people haven’t pounced? If he’s available in your league GRAB HIM! START HIM!Fool’s goldAll of the 49ers wide receivers% Owned: Don’t get us started (again)Another week where none of the wide receivers outside of Kendrick Bourne do much of anything. We said wait a couple weeks and we weren’t kidding. If Sunday’s performance means anything, you may want to look at dropping them all. We say wait another week. The 49ers wide receivers are dealing with injuries and C.J. Beathard is trying to find a go-to pass catcher. For now, that’s Kittle, but defenses are going to figure that part out and he’ll have to go to the wide receivers. Give them another week, then drop accordingly, starting with Pierre Gar莽on. Drop or don’t drop: Wait one more week.